P092 Co-administration of 5-aminosalicylic acid to 6-mercaptopurine reduces in vitro hepatotoxicity

Fatal hepatotoxicity associated with 6-mercaptopurine therapy.

Electrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media

5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...

aminosalicylic acid to 5-aminosalicylic acid in topical treatment of ulcerative colitis. Digestion

Nephrotoxic lesions from 5-aminosalicylic Acid.

5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...

electrochemical synthesis of 5-aminosalicylic acid from 5- nitrosalicylic acid in alkaline media

5-aminosalicylic acid (5-asa) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-nsa) in acidic media. in this work, electrolytic reduction of 5-nsa in alkaline media is presented. reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the ph for isolation of product are investigated. the yiel...